Category: News

26 Jun 2014

4Dx tests Andor Tech’s Zyla sCMOS HF camera

We were recently approached by Andor Technology PLC to test their new Zyla sCMOS HF camera ahead of release. Andor Technology is a developer and manufacturer of high performance light measuring solutions (scientific digital cameras). Andor became a subsidiary of Oxford Instruments after it was purchased in December 2013.

As part of our testing program, we took multiple sequences of images using the Zyla sCMOS HF camera with our pre-clinical laboratory scanner. One of our images was chosen by Andor Technology to feature in the Zyla sCMOS HF product specification, and also on the front cover of their High Energy Detection brochure.

28 Mar 2014

Research ventilator development update

As part of our ongoing research and development activities, we have the need for robust, precise ventilation strategies — ideally interchangeable between physiological profiles and standard pulmonary function test manoeuvres.

Although many off the shelf research ventilators are available, our extensive and varied technical needs led us to engineer our own pressure-driven research ventilator, capable of delivering very small volumes of air gently. Additionally, we have integrated full trigger control synchronisation, for paired use with our complex X-ray imaging, bio-monitoring and nebulisation systems.

We have fine tuned our ventilator’s design, footprint and functionality over the years to suit our ever changing and increasingly complex R&D requirements. We now have a highly specialised and versatile small animal ventilator in our hands with significant operational flexibility through storable, user programmable macros. Suitable to ventilate a variety of small laboratory animals, our BreathVent research ventilator measures air pressure, flow, and will continuously ventilate across a broad range of volumes, pressures and respiratory rates.

Compared to more traditional piston driven and flow restrictor ventilators, our BreathVent ventilator is stable and accurate, with increased change response performance for inspiration, peak inspiration and expiratory pressure times, through the use of fast switching controller valves.

The ventilator unit is self-contained, compact and lightweight, making it suitable for travel (from our own practical need to bring it back and forth from the SPring-8 Japanese Synchrotron and to our collaborators’ research laboratories across Australia). It is small enough to squeeze into the tightest, space-poor experimental laboratories.

21 Nov 2013

Steve wins Stephen Wilkins Medal for technology

Congratulations to Steve, who today was presented with the inaugural Australian Synchrotron Stephen Wilkins Thesis Medal (2013) at the 2013 Australian Synchrotron User Meeting. The Australian Synchrotron Thesis Medal, now named in honour of the late Dr Stephen Wilkins, is awarded to annually to the most outstanding Australian or New Zealand thesis of the past two years whose work was undertaken at and acknowledges the Australian Synchrotron, or the Australian National Beamline Facility (ANBF), or whose work acknowledges and was undertaken under the auspices of the International Synchrotron Access Program (ISAP).

Steve’s thesis includes the developmental work of our 4D lung imaging technology, a four-dimensional lung X-ray imaging technology. The award recognises his practical lung imaging methods for blood flow and tissue movement in the lungs applied to various lung disease models such as asthma, cystic fibrosis, and emphysema. With the support of the Australian Synchrotron’s International Synchrotron Access Program, Steve travelled to the SPring-8 synchrotron in Japan over a dozen times, spending more than 3000 hours conducting experiments and refining his X-ray imaging methods.

Image courtesy: The Australian Synchrotron.

19 Nov 2013

Andreas receives Excellence Award for technology

Congratulations Andreas, who tonight was awarded the 2013 Monash University’s Vice-Chancellor’s Award for Excellence in Research by an Early Career Researcher. This exclusive award recognises Andreas’s development of the 4D X-ray lung imaging technology to improve human health.

The ceremony was held in Flemington, and addressed with a keynote by Victorian Premier Hon. Dr Denis Napthine to 200 attendees, including representatives from industry, Government, Monash University and award nominees.

Andreas pictured with Vice-Chancellor’s Award for Teaching Excellence recipient and Dept. Mechanical and Aerospace Engineering colleague Dr Kris Ryan.

01 Jul 2013

4Dx opens Melbourne office

With the beginning of the new financial year, we are pleased to announce that after successfully raising $1 million in seed capital, we have opened our Melbourne office and commenced operations. As a medtech startup, we plan to commercialise our 4D lung imaging software technology, an entirely new approach for pulmonary function testing, with the goal to bring our innovative software technologies into hospitals all over the world. A key ingredient in our progress to date has been support from Commercialisation Australia in the form of mentoring and a Skills and Knowledge Grant.

Lung disease results in the hospitalisation of 350,000 Australians each year and the escalating costs and lack of insight into these lung diseases is increasingly becoming a serious health issue. In fact Chronic Obstructive Pulmonary Disease is the only one of the world’s top ten killers with an increasing death rate. These matters are not unique to Australia, with over 440,000 Americans dying from lung cancer last year.

28 Jun 2013

Commercial use licence of our lung imaging technology secured

We have successfully completed negotiations with Monash University for exclusive commercial use of our 4-dimensional imaging technology. The agreement covers multiple separate patents that apply across all current major target geographies.

My research team at LDI developed the technology which directly images lung function in the breathing lung, something typically inferred from static images of the lungs’ shape. The technology presents an entirely new approach to pulmonary function testing and has the potential to make a difference in the diagnosis, treatment and management of lung diseases. This technology will detect changes in lung function sooner, with far less radiation than a standard CT scan, and has the potential to revolutionise the way we treat lung diseases.

28 Mar 2013

Tribute to X-ray imaging pioneer Steve Wilkins

It is with great sadness that we remember Australian X-ray physicist Dr Stephen William Wilkins, who suddenly passed away in Melbourne on the 25th of March 2013. Steve’s major contributions to the areas of X-ray methods and X-ray instrumentation paved the way for widespread implementation of hard X-ray phase-contrast imaging in research, as well as in industry and medicine, all areas of which our group’s work belongs. It is by no exaggeration that Steve’s pioneering work forms the solid ground from which our group’s own hard X-ray phase-contrast imaging techniques are based.

Steve’s most influential and highly cited papers: