The AccuVent 200 is a highly versatile small animal ventilator that provides respiratory and pre-clinical researchers with exceptional accuracy and stability.
Who is the device for?
Because the AccuVent is such an adaptable piece of equipment, there is no single type of researcher it will suit above others.
It’s applicable to studies in:
Lung function (and its measurement)
Lung injury (the ventilator can induce injury in
Respiratory allergen response, including asthma
Lung disease, including cystic fibrosis
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Download the AccuVent 200 Spec Sheet
In creating the AccuVent, we’ve dispensed with the traditional piston-driven cylinder arrangement and developed a dual-chamber model that includes no moving parts besides the electromechanical valves. Pressure is precisely controlled for both inspiration and expiration, which allows for numerous advantages when compared with other ventilators.
A ventilator for imaginative research
Designed with novel research in mind, the AccuVent is a tool that encourages investigators to exercise their scientific imaginations.
We’ve built the device to work in a variety of ways and to accommodate a multitude of new protocols – all without the need to use up precious time switching equipment or swapping parts.
Small, versatile and adaptable
It’s capable of ventilating numerous small laboratory animals, measuring air pressure and flow, and ventilation across a range of volume, pressure and respiratory rates. It’s also the only high-frequency ventilator on the market.
The AccuVent takes up about the bench space of an A4 sheet of paper and can be turned onto its side to reduce its footprint without altering its performance in any way.
Optional add-ons are available which allow for pre-clinical imaging, delivery of gases and delivery of aerosolised solutions and pharmaceuticals.
Live feedback and intuitive software
As a researcher, you can expect to receive constant feedback while you use the device thanks to the sophisticated 4Dx software on which it runs.
The AccuVent operates with a simple-to-use control software interface (which works with Windows XP, Vista, 7, 8.1 and 10). It features programmable, storable macros for the most complex ventilation strategies.
Dependable, precise and gentle
Compared to piston-driven and flow restrictor ventilators on the market, the 4Dx AccuVent is significantly more reliable, due in great part to its design . We understand that for the majority of research, repeatability is vital, and we’ve designed our product to be highly accurate from one experiment to the next, and from one device to the next.
Extremely precise control and the removal of pistons delivering set volumes means extremely safe experiments; gentleness to animals is a central feature of the device.
The AccuVent offers increased change response performance for inspiration, peak inspiration and expiratory pressure times, through the use of fast switching controller valves. Users can expect respiratory rates up to 33Hz and a maximum breath rate of 1800 BPM.
|Maximum Breath Rate||30Hz 1800 BPM||10Hz 600 BPM||5Hz 300 BPM|
|Tidal Volume||Only limited by flow rate||1.5-28ml||0.05-5ml|
|Inspiration Pressure||-80 to 80cm H20||0 to 80cm H20||0 to 50cm H20|
With its 30Hz 1800 BPM, the AccuVent offers users superior flexibility. Having a Tidal Volume only limited by flow rate, the AccuVent delivers long positive pressure breath holds. Unlike the other ventilators compared, only AccuVent is capable of negative pressure settings. With its competitive pricing and aftersales support, AccuVent is the smart choice for research laboratories.
*Data based on publicly sourced information.1
FLEXIVENT® is a trademark of SCIREQ Scientific Respiratory Equipment Inc.
VENTELITE® is a trademark of Harvard Bioscience.
1. Flexivent specifications sourced from Scireq website. Ventelite specifications sourced from Harvard Apparatus website.
Pioneering piston-free design
Easy to operate
Superior operational flexibility
Capacity to measure airway pressure and flow
Negative pressure setting option
Capacity to conduct high-frequency ventilation
Independent inspiratory and expiratory pressure systems
Pressure and volume based control options
Wide range of tidal volume and respiratory rates
User-defined breathing pattern macros
Option to synchronise with external devices and inputs
Advanced timing control functionality
Intubation Light — Helps the user locate the trachea to insert a cannula in as it is often difficult to distinguish between the trachea and the oesophagus in small animals.
External Pumps — For use in rooms without pressurised air and vacuum lines.
Nebulizer Control Add-on — Controls an Aeroneb® Lab Nebuliser (sold separately). Can be modified to control other nebulisers. Contact 4Dx for additional details.
Customer Specific Add-ons — 4Dx can develop software to suit your specialised needs. Contact us to discuss your requirements.
Nebulizer Control Add-on
What the Users Say
One AccuVent user is a prominent US-based researcher and specialist in the field of pulmonary medicine. She works for several institutions around the world and so preferred not to be named for this article.
She requires high-precision research for some of her projects and needs to ventilate several mice at the same time.
“I used an AccuVent in some experiments in Australia with collaborators, and was impressed with the clearly superior technology and fine control of the settings, so when I finally got fed up with my old ventilators, I knew that the AccuVent was the only ventilator I could afford that I actually trusted,” she says.
When she talks about “superior technology” her point of comparison is other ventilators that she used before trying AccuVent. Her experience wasn’t quite so good.
“They are woefully inaccurate even in terms of volume control; I have two identical ventilators with digital dial-in for volume settings that deliver tidal volumes that are vastly different for the same digitally set volume, especially at volumes less than 500 ul,” the researcher explains.
“One ventilator gives volumes that are 30-50% higher, the other ventilator delivers volumes that are 50-80% lower than the set volume, so every time I did an experiment I would have to individually calibrate each ventilator for the actual volumes I needed. Therefore, I was highly sceptical of the ability of these machines to deliver precise or accurate pressure control ventilation.”
Apart from offering vastly improved accuracy, AccuVent allowed the researcher to improve the efficiency, and so the speed, of her work. She studies lung injury in mice caused by a ventilator and her work involves exposing the animals to between four and six hours of mechanical ventilation.
“As a junior faculty member trying to get preliminary data for a grant, I had limited time in the lab and limited funds, so the AccuVent’s ability to ventilate multiple animals from one vent was critical to my success,” she says.
“Many researchers perform these experiments on one to two mice per day, because they only have one or two ventilators; I think this adds an element of variability that is less than ideal, and in addition it is very difficult to generate data when each experiment takes many days to get adequate numbers.”
This sophistication, she says, allows her a more nuanced level of lung measurement. She believes that the thought and engineering precision that has gone into the design of the device stands out.
“With the AccuVent I am able to add an entirely new read-out of lung compliance to my measures of lung injury, because this ventilator can measure both volumes and pressures accurately. The only other ventilator on the market that can do this is the flexiVent, which was way out of my price range.
“My AccuVents are also very intuitive to use, and the technical support from the company has been outstanding, as well. They require a laptop to run, and you can also customise the respiratory sequences to add sigh breaths and do pressure-regulated volume control as well. I think the AccuVent is clearly the next wave in small animal ventilators.
“I can’t imagine ever using or needing something else.”
Dr Martin Donnelley
Biomedical Engineer, Adelaide Cystic Fibrosis Gene Therapy Research Group at the Women's and Children's Hospital
Researcher and biomedical engineer, Dr Martin Donnelley is a specialist in respiratory disease, and has a particular interest in cystic fibrosis (CF). For much of his career his research has been centred on using synchrotron X-ray light to image airway surfaces so as get a better picture of how effective gene therapy and pharmaceutical treatments might be for CF.
He uses Notting Hill Devices’ AccuVent as part of this research.
“[CF] is a lung disease caused by mutations in a single gene called CFTR. People that have it end up with dehydration of the airway surface. The mucociliary clearance system doesn’t work properly – that’s the coordinated beat of cilia, the tiny little hair-like structures on the airway surface. They clear mucus and particulates,” Dr Donnelley explains.
“So what we’re doing is using high-magnification imaging to look at mucociliary clearance in normal and CF animal models to look at how that’s affected with treatments.”
He says to undertake such research properly, extremely high levels of detail and accuracy are essential, and this is one of the reasons he feels the AccuVent suits his requirements particularly well.
“We typically need to be able to do imaging studies where we capture one or more images per breath at the Synchrotron. We need good gating to be able to capture motion-free images. That’s why the Accuvent works so nicely: it’s quick and simple to set up and we can produce an accurately timed trigger that drives our imaging capture equipment.”
The gating that Dr Donnelley refers to is essential for his work, and for the work of many researchers and scientists in the field, and is easily accomplished with the AccuVent.
“Gating allows us to capture an image at the same point in each breath. We can get the unit to output a trigger so we can get our camera and shutter system to collect images at exactly the same point in the breath. Otherwise we don’t know where those images are being acquired if they’re not ‘gated’ to the ventilator,” Dr Donnelley says.
He says the device is “very reliable” in its own right, but also very flexible when compared to other ventilators he’s used for the same work.
“We’ve used ventilators from other companies, and any time we needed changes to physical or software components this was slow or not possible.
“One of the advantages of dealing directly with Notting Hill Devices was being able to say ‘We’d like it to be able to do this…’ and ‘This didn’t function in the way we expected…’ and that was fairly rapidly corrected and made into new software. So software updates and software development are definitely better.”
Associate Professor Graeme Zosky
Associate Professor in Physiology, Faculty of Health, University of Tasmania
Researcher and Associate Professor at the University of Tasmania, Associate Professor Graeme Zosky has been studying lung disease for more than a decade. His research in the School of Medicine at the Medical Sciences Precinct in Hobart focuses on the early life origins of chronic lung disease.
He says the AccuVent has worked well in his laboratory work for a variety of reasons.
“The AccuVent is ideally suited to the studies we have been conducting because it allows accurate pressure control and provides the precision timing necessary for integration with imaging at high frame rates,” Dr Zosky explains.
As part of his work, Associate Professor Zosky covers a range of fields within respiratory science, including the early life determinants of lung growth and the design of novel techniques for the assessment of lung structure and function.
“We are using the AccuVent in experiments that aim to understand the fundamental response of the lung to positive pressure ventilation and why this type of ventilation can cause lung injury and death in critically ill patients,” Associate Professor Zosky says.
His experience so far with the device has been extremely positive. Associate Professor Zosky says it compares favourably with other ventilators and can be depended on in multiple experiments.
“We have found the AccuVent to be extremely versatile and reliable. The quality of the imaging data we obtain would not be possible using other ventilators currently on the market.”